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Membranes
Made of bilayer systemMade of phosopholipids (phospholipid bilayer)Glycerol
(backbone), 2 Fatty Acids & Alcholphoshate group

Proteins present in membraneSemi-permeable; selectivily permiableFluid
mosaic modelMembranes are fluidSpinSwitch placesFlip flopMore unsaturated
~> more fluidColder ~> less fluidProteins-
Can more, but cannot move out of membrane
Stabilizing Factors
Hydrophobic interactions that keep bilayer intactH-bonding w/ phosphateCholesterol
~> seperate phospholipids
Destabilizing Factors
Double bonds in fatty acids ~> more fluid, but less stableRotation
& flipping of phospholipid
Transmembrane Proteins
Enzymes - Membrane bound
Increase efficiency of metabolic rxns.
Receptor - Transmit information from outside the cell to the inside
Hormones - specific site & will change conformation of protein
inside the cellProstaglandin - (pain response)
Anti-inflammatory agentsEffects of aspirin
Anti-bodies
Channel Proteins - passive transport across the membrane (ex. Na+/K+
pump)Carrier Proteins - active transport across the membrane (ex. Sugar
Transport)
Cell Surface Markers
Glycocalyx - layer on outside composed of sugarsGlycoprotein - "self
recognition" - recognizes individuals (ex. Major Histocompatability
Complex (MHC))Glycolipid - Tissue recognition (ex. A,B,O Blood Groups)
Interior Protein Network
Spectrin - determines shape of cell; provides an internal structureClatharin
- Anchor proteins especially during receptor mediated endocytosis
5 ways they Regulate Movement
OsmosisDiffusion (passive transport)Bulk passive - phagocytosisReceiving
InformationPhysical connection between cells
Movement of Materials Across Membrane
Large polar molecules which are uncharged & ions cannot pass freely
(Glucose, Cl-, Na+, K+, C++,
proteins)Small-uncharged polar molecules and hydrophobic molecules can
pass freely (ex. H2O, CO2, O2, hydrocarbons)Two
Types of Movement:
Diffusion -
Movement of materials from high to low [ ]Low random motion dependent
on concentration gradientSmall Uncharged molecules free to pass
through membrane
Facilitated Diffusion -
Movement from high to low [ ]Moderate to large size moleculesRequire
channel proteins to help them inDepend on [ ] gradient & channel
availability
Osmosis -
Hydrostatic Pressure -
Pressure exerted by cytoplasm pushing on membrane
Osmotic Pressure -
Increase in hydrostatic pressure due to movement of H2O
into cell*Used to stop Osmosis*
Turger Pressure -
Created by pressure of fluid against cell wall*Wilting*Central
Vacuole
Plasmolysis -
Shrinking of membrane due to H2O loss
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